14 CLINICAL STUDIES

Related/similar drugs
Renal Dose Adjustments
5.9 Renal Impairment
See also:
Liver Dose Adjustments

pentobarbitalpentobarbital will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. pentobarbital will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. phenobarbitalphenobarbital will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. phenobarbital will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. phenytoinphenytoin will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

Country	Regulatory Authority	Approval Status	Notes
United States	FDA	Approved for ED	Prescription required
European Union	EMA	Approved	Prescription required
Canada	Health Canada	Approved	Prescription required
Australia	TGA	Approved	Prescription required

phenytoin will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. posaconazoleposaconazole will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Vardenafil dose may need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors posaconazole will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

Brand Name	Manufacturer	Formulation Type	Price Range	Notes
Levitra	Bayer	Tablet	Moderate	Widely used
Staxyn	Bayer	Orally disintegrating tablet	Similar price	Alternative formulation
Generic Vendors	Multiple	Tablet	Lower	Cost-effective option

Vardenafil dose may need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors prednisoneprednisone will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

Vardenafil 10 mg is a popular choice for ED treatment.
Dose can be adjusted by a healthcare provider.
Avoid using vardenafil with recreational drugs like poppers.
Do not use after consuming large amounts of alcohol.
The pill is generally taken before planned intercourse.
Its effects are dose-dependent and subject to individual variation.
Adherence to prescribed dose helps prevent adverse effects.
The medication can be used long-term if prescribed.
Regular checkups can help monitor effectiveness and safety.
Never double the dose if the first does not work immediately.

prednisone will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

Vardenafil is generally safe when used as prescribed.
The tablet is typically taken around 30 minutes before sex.
Alcohol may enhance side effects like dizziness.
Do not use vardenafil if you are taking nitrates.
Keep a schedule of your medication use.
Inform your doctor about other medications you are taking.
Use only prescribed dosage to prevent adverse effects.
Avoid certain foods that may interfere with absorption.
Healthcare providers may adjust doses based on response.
Proper storage extends the shelf life of the medication.

primaquineprimaquine and vardenafil both increase QTc interval. primaquine and vardenafil both increase QTc interval.

Related/similar drugs

mirtazapine and vardenafil both increase QTc interval. mitapivatmitapivat decreases levels of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor patients for loss of therapeutic effect of sensitive CYP3A substrates with narrow therapeutic index when coadministered with mitapivat. mitapivat decreases levels of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. mitotanemitotane decreases levels of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

Drug Interactions

Mitotane is a strong inducer of cytochrome P-4503A4; monitor when coadministered with CYP3A4 substrates for possible dosage adjustments. mitotane decreases levels of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. nefazodonenefazodone will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Vardenafil dose may need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors nefazodone will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Vardenafil dose may need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors nelfinavirnelfinavir will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. primidoneprimidone will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

Product	Dosage	Quantity + Bonus	Price
Cialis Original	20mg	64 + 4 Pills	274.18€ 261.12€
Kamagra Oral Jelly	100 mg	30 + 5 Sachets	136.20€ 129.71€
Levitra Generic	10mg	270 + 10 Pills	338.09€ 321.99€
Cialis Professional	20mg	360 + 6 Pills	807.03€ 768.60€
Viagra Generic	100mg	30 + 4 Pills	60.91€ 58.01€
Kamagra Soft Tabs	100mg	272 + 12 Pills	593.42€ 565.16€
Cialis Generic	10mg	20 Pills	48.23€ 45.93€
Levitra Original	20mg	76 + 4 Pills	344.39€ 327.99€
Viagra Generic	100mg	360 + 10 Pills	330.21€ 314.49€
Kamagra Effervescent Tablets	100 mg	28 Pills	90.83€ 86.50€
Cialis Original	20mg	22 + 2 Pills	129.20€ 123.05€
Kamagra Polo	100 mg	12 Pills	60.21€ 57.34€
Viagra Soft Tabs	100mg	90 + 6 Pills	205.31€ 195.53€
Viagra Generic	200mg	360 + 10 Pills	481.98€ 459.03€
Viagra Generic	200mg	180 + 10 Pills	277.56€ 264.34€

primidone will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Either increases toxicity of the other by QTc interval. Avoid use with drugs that prolong QT and in patients with risk factors for prolonged QT interval. Postmarketing cases show QT prolongation with overdose in patients with concomitant illness or with drugs known to cause electrolyte imbalance or prolong QT.

Renal Dose Adjustments

olanzapine and vardenafil both increase QTc interval. olodaterol inhaledvardenafil and olodaterol inhaled both increase QTc interval. Drugs that prolong the QTc interval and may potentiate the effects of beta2 agonists on the cardiovascular system; increased risk of ventricular arrhythmias vardenafil and olodaterol inhaled both increase QTc interval. osilodrostat and vardenafil both increase QTc interval. Conduct periodic monitoring with ECGs and electrolytes in patients taking drugs known to prolong the QTc interval.

Usual Adult Dose for:

osimertinib and vardenafil both increase QTc interval. ozanimodozanimod and vardenafil both increase QTc interval. The potential additive effects on heart rate, treatment with ozanimod should generally not be initiated in patients who are concurrently treated with QT prolonging drugs with known arrhythmogenic properties. ozanimod and vardenafil both increase QTc interval. vardenafil and pasireotide both increase QTc interval. quininevardenafil and quinine both increase QTc interval.

The onset of vardenafil 10 mg is typically 30-60 minutes.
It can last up to 4-5 hours in some users.
Vardenafil is contraindicated with certain heart medications.
Use caution if you have a history of hypotension.
The tablet may cause mild gastrointestinal upset.
Do not consume large amounts of alcohol when taking vardenafil.
Inform your doctor if you experience sudden hearing loss.
Use only as directed by your healthcare provider.
Discontinue if you experience persistent erection issues.
The medication does not increase sexual desire.

vardenafil and quinine both increase QTc interval.

5.9 Renal Impairment

lenacapavir will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Limit vardenafil dose to 2.5 mg/24 lithiumlithium and vardenafil both increase QTc interval. lithium and vardenafil both increase QTc interval. lonafarniblonafarnib will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. If coadministration unavoidable, monitor for adverse reactions and reduce CYP3A substrate dose in accordance with product labeling.

Does vardenafil interact with other medicines (drug interactions)?

lonafarnib will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. lopinavirlopinavir will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Vardenafil dose may need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors lopinavir will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Vardenafil dose may need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors lumefantrinelumefantrine will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. lumefantrine will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor patients more frequently with ECG if coadministered with QT prolonging drugs. relacorilantrelacorilant increases levels of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

Liver Dose Adjustments

mavorixaformavorixafor will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor QTc during treatment in patients with risk factors for QTc prolongation (eg, coadministered medications that increase mavorixafor exposure or other drugs with a high risk to prolong the QTc interval). Mavorixafor dose reduction or discontinuation may be required. mavorixafor will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor for adverse effects of sensitive CYP3A4 substrates if coadministered with mavorixafor (a weak CYP3A4 inhibitor).

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methylprednisolone will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. metronidazolemetronidazole will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Vardenafil dose may need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors metronidazole will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Vardenafil dose may need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors Use alternatives if available.mifepristone will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Vardenafil dose may need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors mirtazapinemirtazapine and vardenafil both increase QTc interval. relacorilant increases levels of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. ECG monitoring recommended if concomitant use can?t be avoided and withhold therapy if QTc interval is >480 msec; restart therapy after QTc interval returns to <480 msec revumenib and vardenafil both increase QTc interval. ECG monitoring recommended if concomitant use can?t be avoided and withhold therapy if QTc interval is >480 msec; restart therapy after QTc interval returns to <480 msec ribociclibribociclib will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Vardenafil dose may need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors ribociclib will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

Some users may experience mild flickering vision episodes.
The efficacy of vardenafil varies between individuals.
The medication is available in various dosage forms.
Always follow the specific instructions provided.
Avoid taking vardenafil with high-fat meals to speed absorption.
Do not take vardenafil if allergic to its ingredients.
The drug may cause a temporary burning sensation.
Use caution in patients with a history of priapism.
Avoid combining vardenafil with certain herbal supplements.
Consult your doctor about any ongoing health treatments.